In the field of aesthetic care, skin fillers are widely used as a non-surgical alternative or supplement to surgery, and they have gained acceptance from both caregivers and patients. They are now the second most popular non-surgical procedures. Among the various dermal fillers available, Calcium Hydroxylapatite (CaHA) is becoming increasingly popular. Currently, only Radiesse® (Merz North America, Inc., Raleigh, NC, USA), a CaHA filler, has obtained FDA approval for long-lasting correction of moderate to severe wrinkles and folds, with results lasting 12 to 18 months.
Epistudia, in collaboration with Merz North America, conducted a comprehensive analysis to explore the aesthetic effects of Radiesse and the potential mechanisms behind them. Our study, published in Frontiers in Medicine, summarized data from 12 studies. The overall findings indicated that CaHA promotes cell proliferation, collagen production, angiogenesis, as well as the formation of elastic fibers and elastin. These mechanisms contribute to skin regeneration, volume enhancement, and contouring.
However, it is important to note that the quality of evidence available on this topic is generally low, underscoring the need for future studies with improved quality.For more information, you can access our study through the following link:
https://www.frontiersin.org/articles/10.3389/fmed.2023.1195934/abstract
